Los ácidos micólicos, en específico, poseen funciones biológicas importantes, entre las que se encuentra el papel que desempeñan en la persistencia de la. como los ácidos micólicos, ácido micoserósido, fenoltiocerol, lipoarabinomanano y arabinogalactano contribuyen a la longevidad, a la respuesta inflamatoria. Aunque el análisis de los lípidos de la pared celular (ácidos micólicos) mediante cromatografía líquida de alta presión es una opción Buena y bien conocida, los.

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Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis.

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Annu Rev Biochem ; Inhibition of the Staphylococcus aureus NADPH-dependent enoyl-acyl carrier protein reductase by triclosan and hexachlorophene. Biosynthesis of mycobacterial lipoarabinomannan: The history of the Ziehl-Neelsen stain. Inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosisby triclosan and isoniazid. Probing mechanisms of resistance to the tuberculosis drug isoniazid: Tuberculosis, focus on tropical diseases.

Characterization of the catalase-peroxidase gene katG and inhA locus in isoniazid-resistant and -susceptible strains of Mycobacterium tuberculosis by automated DNA sequencing: The practice of medicinal chemistry. Currently, lipid antigens of mycobacteria are attractive targets for the development of new tuberculosis vaccinal formulations.

These results indicate the relevance mkcolicos continuing immunoprotection studies with mycobacterial acieos antigens. Drug Targetsv. Estes pesquisadores isolaram cepas de E. In conjunction with the spread of HIV infection, tuberculosis TB has been among the worldwide health threats. The envelope of mycobateria. Molecular Microbiology ; Conformational changes caused by inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis.


Does antibody to mycobacterial antigens, including lipoarabinomannan, limit dissemination in childhood tuberculosis? J Biol Chem ; Lipid biosynthesis as a target for antibacterial agents.

Targeting tuberculosis and malaria through inhibition of enoyl reductase: Em geral, as tiofeno-diazoborinas foram os inibidores mais potentes, seguidos pelas benzo-diazoborinas e furano-diazoborinas, enquanto que as pirrol-diazoborinas foram totalmente inativas.

Enoyl reductases as targets for the development of anti-tubercular and anti-malarial agents.

Ácido micólico – Wikipedia, a enciclopedia libre

Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis. Mechanistic diversity and regulation of Type II fatty acid synthesis.

Water Res ; Mycobacteria resistance to the drugs currently used in the therapeutics is the main mcolicos of TB resurgence. Trends in Microbiology ;9 Clarity through the scope of genetics.

Global tuberculosis control – surveillance, planning, financing. J Exp Med ; High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis. Constructing protein models for ligand-receptor binding thermodynamic simulations: Nat Rev Microbiol ; 4: The magic bullets and tuberculosis drug targets.

These provide valuable opportunities for structure- or catalytic mechanism-based design of selective inhibitors as novel anti-TB drugs with improved properties. Strategies in the search for new lead compounds or original working hypothesis.


An approach for the rational design of new antituberculosis agents. Evaluation of Mycobacterium smegmatis as a possible surrogate screen for selecting molecules active against multi-drug resistant Mycobacterium tuberculosis. Infect Dis Clin N Am acido Lepr Rev ; 68 4: Quantitative structure -based design: Chemotherapy of experimental tuberculosis – VII. Receptor-independent four-dimensional quantitative structure-activity relationship analysis of a set of isoniazid derivatives.

A triclosan-resistant bacterial enzyme. Surface glycopeptidolipids of M. In view of this severe situation, the new and selective anti-TB design is of utmost importance.

Some observations on the pathogenicity of isoniazid-resistant variants of tubercle bacilli. Overexpression of inhA, but not kasAconfers resistance to isoniazid and ethionamide in Mycobacterium smegmatisM.

Ácido micólico

Rational approach in the new antituberculosis agent design: Identification of the surface-exposed lipids on the cell envelopes of Mycobacterium tuberculosis and other mycobacterial species. This paper highlights recent approaches regarding the design of new anti-TB agents, particularly, the enoyl-ACP reductase inhibitors.

A study of the structure-activity relationship for diazaborine inhibition of Escherichia coli enoyl-acp reductase.