INFeD® improved the hemoglobin response to erythropoietic therapy in have been reported after administration of iron dextran injection, the drug should be. iron dextran – Drug Summary. Jump to INFeD Intramuscular Inj Sol: 1mL, 50mg . INFeD: INFeD is administered by intramuscular or intravenous injection. Allergan, Inc.: Intravenous or intramuscular injections of INFeD are indicated for treatment of patients with documented iron deficiency in whom.
|Published (Last):||23 March 2018|
|PDF File Size:||4.74 Mb|
|ePub File Size:||18.64 Mb|
|Price:||Free* [*Free Regsitration Required]|
If necessary, iron may be given in short courses, but since iron and trientine each inhibit oral absorption of the other, 2 hours should elapse between administration of trientine and iron doses.
INFeD should be injected only into the muscle mass of the upper outer quadrant of the buttock — never into the arm or other exposed areas — and should be injected deeply, with a 2-inch or 3-inch 19 or 20 gauge needle.
Iron dextran (INFeD)
Ankylosing spondylitis, asthma, atopy, rheumatoid arthritis, systemic lupus erythematosus SLE. It would be illogical for a patient to receive both iron supplementation and deferasirox simultaneously. Inject via slow IV at a gradual rate not to exceed 50 mg 1 mL per minute for adults; take care to inject dosage very slowly in children and infants.
Do not administer iron during dimercaprol treatment. Pediatric Use Alternatively the total dose may be calculated: Because anaphylactic reactions are known to occur after uneventful test doses, test doses before subsequent doses should be considered.
Unnecessary or prolonged administration of iron may lead to iron overload and consequently the possibility of exogenous hemosiderosis.
Because anaphylactic reactions are known to occur after ;ackage test doses, subsequent test doses should be considered. Infants and Children 4 months and older weighing 5 to 9.
Am J Kid Dis. Observe the patient for at least 1 hour after test dose administration. While iron is excreted into breast-milk, the iron content of breast milk is not readily affected by the iron content of the maternal diet or the maternal serum iron level. There is no destructive metabolism of iron because it takes place in a closed system.
If test dose uneventful, infuse the remainder of the total calculated dose IV over 2 to 6 hours. Safety and efficacy have not been established. Patients with hepatic disease should receive iron dextran with caution. Iron content infsd hemoglobin. Iron Deficiency Anemia are not applicable for simple iron replacement values. Furthermore, concomitant use of angiotensin-converting enzyme inhibitors may increase the risk for serious reactions to iron dextran.
Dilution Iron Dextran (imferon ®) – GlobalRPH
See individual dosage if using total dose IV infusion methods. Moderate The concomitant use of angiotensin-converting enzyme inhibitors ACE inhibitors with iron dextran may increase the risk for anaphylactic-type reactions. Test dose [25 mg] [ ml] [5 min] [Prescribed dose] [ to ml] Usually ml NS Total dose infusion: Major Deferiprone chelates iron.
The use of iron dextran to prevent iron deficiency in patients requiring long-term parenteral nutrition support is controversial; some experts advocate the use of iron to treat a deficiency if it occurs vs.
Adults, Adolescents, and Children weighing more than 15 kg. Severe Deferoxamine chelates iron from ferritin or hemosiderin. A test dose of 25 mg infused over 5 minutes should be given. In general, iron supplementation should not begin in premature infants until adequate vitamin E is supplied in the diet; human breast milk and modern infant formulas usually supply adequate dietary vitamin E. Observe patient for at least 1 hour after test dose administration.
Use iron dextran with caution in patients with hepatic disease. Fatal reactions have occurred following the test dose of iron dextran and also have occurred after other doses when the test dose was tolerated. The liver is one of the main storage sites for iron, and some patients with chronic liver disease may have excessive iron storage.
Hemosiderosis secondary to long-term iron dextran treatment has primarily been reported in patients with renal failure receiving dialysis.
Severe Dimercaprol forms toxic chelates with iron. Therapeutically, it is typically illogical for a patient to receive both iron supplementation e.
Once taken into reticuloendothelial cells, the iron from the iron dextran complex is separated and added to the body’s total iron stores.
Iron dextran (INFeD) | – A Hematology Oncology Wiki
Consider the benefits of breast-feeding, the risk of potential infant drug exposure, and the risk of an untreated or inadequately treated condition. Iron stores are utilized in erythropoiesis and can be depleted during therapy even in patients with packaeg pre-treatment iron concentrations. Since deferiprone has the potential to bind polyvalent cations e.
Infants and Children 4 months and older weighing less than 15 kg.
Ferric iron is then gradually released into the plasma where it combines rapidly with transferrin. Adults, Adolescents, Children, and Infants 4 months and older. Major Parenteral iron formulas are generally only indicated for use in patients with documented iron deficiency in whom oral administration is either impossible or unsatisfactory. Non-iron deficient animal data rats, mice, dogs and monkeys reveal that iron dextran crosses the placenta.
Patients with hemoglobinopathy and other refractory anemias that might be erroneously diagnosed as iron deficiency anemias are at particular risk for such iron overload.
Use actual body weight if less than lean body weight. Parenterally administered iron does not give a faster response compared to oral administration, therefore, the rate of recovery from anemia should be the same.
If no adverse reactions are observed, INFeD can be given according to the following schedule until the calculated total amount required has been reached. Iron supplementation may be needed before and during therapy e.
Total dosage with iron dextran must be individualized according to the patients age, weight, and the degree of infde iron-deficiency anemia. Your email has been sent. To restore hemoglobin and replenish iron stores due to blood loss. However, trace amounts of unmetabolized iron dextran are excreted in breast milk.
Parenteral iron treatment should be administered only when iron deficiency is not correctable iinsert oral treatment. Therapy, thus, should aim at not only replenishment of hemoglobin iron but iron stores as well.